Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 10154224、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:18])[C@@H:9]([O:11]C1CCCCO1)[CH3:10].C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1>C(O)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:18])[C@@H:9]([OH:11])[CH3:10]参加物
4
反応条件
- 温度
- 55 °C
実験手順
(2S)-2′-Fluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone (25 g) was dissolved in ethanol (200 ml), to which pyridinium p-toluenesulfonate (1.28 g) was added. The reaction solution was stirred at 55° C. for 2.5 hours and then concentrated. The residue was subjected to silica gel chromatography (eluent: hexane/ethyl acetate=9/1 to 5/1) to give (2S)-2′-fluoro-2-hydroxypropiophenone (16.4 g) as a colorless oily substance.
後処理
- additionwas added
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-66ae20787e1842d8aec3a220eeedb9d0
- 出典データセット
- uspto-grants-2002_03
- 特許番号
- US06362206B1
反応ノート
読み込み中…