Ethanol hydrochloride → 4,5-dichloro-2-methyl-1-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)-butyl]-1H-imidazole hydrochloride

HRID 2792

反応式

HRID 2792 の反応式
Cl.C(O)C.[Cl:5][C:6]1[N:7]=[C:8]([CH3:28])[N:9]([CH2:12][CH2:13][CH2:14][CH2:15][N:16]2[CH2:21][CH:20]=[C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:18][CH2:17]2)[C:10]=1[Cl:11]>C(O)C>[ClH:5].[Cl:5][C:6]1[N:7]=[C:8]([CH3:28])[N:9]([CH2:12][CH2:13][CH2:14][CH2:15][N:16]2[CH2:17][CH:18]=[C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:20][CH2:21]2)[C:10]=1[Cl:11]

参加物

4

反応物 2

HCID 21887872Ethanol hydrochlorideHCID 219978754,5-dichloro-2-methyl-1-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]-1H-imidazole

生成物 1

HCID 219978744,5-dichloro-2-methyl-1-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)-butyl]-1H-imidazole hydrochloride収率 189.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2.5 ml of an 8.4N hydrochloric acid/ethanol solution are added to a solution, cooled in an ice bath, of 7.4 g (20.3 mmol) of 4,5-dichloro-2-methyl-1-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]-1H-imidazole in 15 ml of absolute ethanol. After a few minutes, a precipitate appears which is filtered, washed with cold ethanol and dried, 7.7 g (19.2 mmol) of 4,5-dichloro-2-methyl-1-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)-butyl]-1H-imidazole hydrochloride being obtained.

後処理

  1. waitAfter a few minutes
  2. filtrationis filtered
  3. washwashed with cold ethanol
  4. customdried

出典と根拠

ORDレコード
ord-4897d8268b054a86a723074d1e00d03f
出典データセット
uspto-grants-1998_03
特許番号
US05731331

関連ノート

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