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Potassium Carbonate → 3-Phenoxybenzyl 2-(2benzothienyl)-3-methylbutanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-(Bromomethyl)-3-phenoxybenzene | HCID 94544 | — |
| 反応物 | 2-(1-Benzothiophen-2-yl)-3-methylbutanoic acid | HCID 23340392 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | tetrahydrofuran HMPA | HCID 86583969 | — |
| 生成物 | 3-Phenoxybenzyl 2-(2benzothienyl)-3-methylbutanoate | HCID 13146350 | — |
反応手順
A mixture of 2-(2-benzothienyl)-3-methylbutanoic acid (1 g, 4.3 mmol), 3-phenoxybenzyl bromide (1.1 g, 4.3 mmol) and K2CO3 (8.6 mmol) in 25 ml of THF/HMPA (1:1) is stirred overnight. The reaction is worked up by diluting with ether, washing with water, drying over Na2SO4, and solvent removed to yield 3-phenoxybenzyl 2-(2benzothienyl)-3-methylbutanoate which can be further purified by preparing thin layer chromatography eluting with 5 percent ether/hexane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04224330 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-d94f0e1a4a804ee5b7e4f30bc6605920 |
| 出典メモ | uspto-grants-1980_09 |