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Methanesulfonate → alpha-Cyano-3-phenoxybenzyl 2-(3-benzothienyl)-3-methylbutanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanesulfonate | HCID 85257 | — |
| 反応物 | Benzeneacetonitrile, alpha-hydroxy-3-phenoxy-, (alphaS)- | HCID 93218 | — |
| 反応物 | Ethyl acetate hexane | HCID 21226206 | — |
| 反応物 | 2-(1-Benzothiophen-3-yl)-3-methylbutanoic acid | HCID 53716412 | — |
| 溶媒 | tetrahydrofuran N,N-dimethylformamide | HCID 21974620 | — |
| 生成物 | alpha-Cyano-3-phenoxybenzyl 2-(3-benzothienyl)-3-methylbutanoate | HCID 54429257 | — |
反応手順
A mixture of 2-(3-benzothienyl)-3-methylbutanoic acid (3.4 mmol) and KCHO3 (3.4 mmol) on 15 ml THF/DMF (1:1) is stirred for about 15 minutes. The mesylate of α-cyano-3-phenoxybenzyl alcohol (3.4 mmol) in 5 ml THF/DMF is added and the reaction mixture stirred for about 48 hours. The reaction is worked up as in Example 2, developing with 10% ethyl acetate/hexane to yield α-cyano-3-phenoxybenzyl 2-(3-benzothienyl)-3-methylbutanoate, colorless thick liquid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04224330 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-62de4d5dcc5440a6a1556c6338ced5c4 |
| 出典メモ | uspto-grants-1980_09 |