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Dimethylformamide → 3-Phenoxybenzyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-(Bromomethyl)-3-phenoxybenzene | HCID 94544 | — |
| 反応物 | 2-(5-Chloro-2-benzothienyl)-3-methylbutanoic acid | HCID 54204673 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 3-Phenoxybenzyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate | HCID 54477689 | — |
反応手順
A mixture of 20 ml DMF, 2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid (0.5 g), K2CO3 (0.51 g) and 3-phenoxybenzyl bromide (0.44 g) is stirred, under nitrogen, for about 15 hours. The mixture is then taken up in ether, washed with water and brine, dried over Na2SO4 and solvent removed. The crude product is plated developing with 10% ether/hexane to give 3-phenoxybenzyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04224330 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-afd7ba97cc11477984f0728908ef7c09 |
| 出典メモ | uspto-grants-1980_09 |