化工社化工社 化学情報印刷レポート · 研究参考用
HRID 279352作成日：2026年10月26日
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 1-(4-Chlorobenzyl)-3-[(4-benzoylbutyryl)amino]homopiperidine
https://huagongshe.com/reaction/279352
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 反応物 | delta-Oxobenzenepentanoic acid | HCID 73914 | — |
| 反応物 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 反応物 | 3-Amino-1-(4-chlorobenzyl)homopiperidine | HCID 18426239 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 1-(4-Chlorobenzyl)-3-[(4-benzoylbutyryl)amino]homopiperidine | HCID 9823008 | — |
反応手順
A solution of 3-amino-1-(4-chlorobenzyl)homopiperidine (24 mg, 0.10 mmol) and 4-benzoylbutyric acid (1.2 equiv.) in CHCl3 (1 mL) was treated with EDCI (23 mg), HOBt (16.2 mg) and Et3N (15.2 μL), and stirred at 25° C. for 16 h. The reaction mixture was diluted with CH2Cl2 (0.5 mL), washed with 2 N aqueous NaOH solution (2×0.75 mL), dried by filtration through a PTFE membrane and concentrated to afford 1-(4-chlorobenzyl)-3-[(4-benzoylbutyryl)amino}homopiperidine (compound No. 994) (43 mg, 99%): The purity was determined by RPLC/MS (98%); ESI/MS m/e 413 (M++H, C24H29ClN2O2).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06362177B1 |
|---|
| 出典データセット | uspto-grants-2002_03 |
|---|
| ORD ID | ord-e90615f838734037a6c71d400c1016f1 |
|---|
| 出典メモ | uspto-grants-2002_03 |
|---|
