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N-[2-[4-[4-formylphenyl]-3-cyclohexen-1-yl]-propyl] 2-propanesulfonamide → N-[2-[4-(4-cyclopentyl)-3-cyclohexen-1-yl]propyl] 2-propanesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-[2-[4-[4-formylphenyl]-3-cyclohexen-1-yl]-propyl] 2-propanesulfonamide | HCID 9841299 | — |
| 反応物 | HCID 178419769 | HCID 178419769 | — |
| 触媒 | HCID 178418476 | HCID 178418476 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-[2-[4-(4-cyclopentyl)-3-cyclohexen-1-yl]propyl] 2-propanesulfonamide | HCID 15541827 | 45% |
反応手順
Prepared as in Example 14, using 100 mg (0.25 mmol) of the material prepared in step A of Example 13, 1.25 ml of a 0.5 M solution of bromo cyclopentylzinc (0.63 mmol) and 9 mg (0.012 mmol) of bis(triphenylphosphine)palladium chloride in 1 ml of THF. Afforded 35 mg (45%) of the title compound. Ion Electrospray Mass Spectrum: M+1=314.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06362230B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-15430aa9e4524157b5005a08db65127e |
| 出典メモ | uspto-grants-2002_03 |