Potassium Hydroxide → (6-Benzoyl-2-pyridyl)methanol

HRID 27937

反応式

HRID 27937 の反応式
[OH-].[K+].C([O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14](=[O:21])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:9]=1)(=O)C>CO.O.[Cl-].[Na+]>[C:14]([C:10]1[N:9]=[C:8]([CH2:7][OH:6])[CH:13]=[CH:12][CH:11]=1)(=[O:21])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

参加物

6

反応物 2

HCID 14797Potassium HydroxideHCID 233378412-(Acetoxymethyl)-6-benzoylpyridine

生成物 1

HCID 20293448(6-Benzoyl-2-pyridyl)methanol

試薬・触媒・溶媒 3

HCID 887Methanol溶媒2 回HCID 962Water溶媒HCID 5234Sodium Chloride溶媒

実験手順

Potassium hydroxide (1.1 g, 18 mmol) is dissolved in 25 ml methanol, after which is added 2-(acetoxymethyl)-6-benzoylpyridine (2.3 g, 9 mmol) in 20 ml methanol and the mixture is then stirred overnight. The mixture is diluted with water and saturated sodium chloride, then extracted with ether (2×), washed with sat. sodium chloride, dried over magnesium sulfate and stripped to yield (6-benzoyl-2-pyridyl)methanol.

後処理

  1. extractionextracted with ether (2×)
  2. washwashed with sat. sodium chloride
  3. dry with materialdried over magnesium sulfate

出典と根拠

ORDレコード
ord-aea147dfdb6a4044b94679de0ec0428e
出典データセット
uspto-grants-1980_09
特許番号
US04224330

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