Hydrazine → (6-Benzyl-2-pyridyl)methanol

A mixture of (6-benzoyl-2-pyridyl)methanol (1.5 g, 7 mmol), potassium hydroxide (1.3 g, 23 mmol) and hydrazine 85% (1 ml, 25 mmol) in triethylene glycol (10 ml) is refluxed for 11/2 hours, and then the water and excess hydrazine are removed by a takeoff condenser until the temperature rises to 195°-200°. After 4 hours at 195°-200°, the solution is cooled, poured into ice and water (50 ml) and extracted with ether (3×20 ml). The combined ether layers are washed with water (3×20 ml), brine (10 ml) and dried over calcium sulfate. Removal of solvents gives (6-benzyl-2-pyridyl)methanol.

1. temperatureis refluxed for 11/2 hours
2. customthe water and excess hydrazine are removed by a takeoff condenser until the temperature
3. customrises to 195°-200°
4. temperaturethe solution is cooled
5. additionpoured into ice and water (50 ml)
6. extractionextracted with ether (3×20 ml)
7. washThe combined ether layers are washed with water (3×20 ml), brine (10 ml)
8. dry with materialdried over calcium sulfate
9. customRemoval of solvents

ORDレコード

ord-e5fa55e5d11d47038609d1a40afb8733

出典データセット

uspto-grants-1980_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04224330