2-Acetamido-4-chloromethylthiazole → 7-((2-Acetamidothiazol-4-yl)methoxy)4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxyquinazoline

HRID 279550

反応式

HRID 279550 の反応式
Cl.[F:2][C:3]1[CH:22]=[C:21]([CH3:23])[C:20]([O:24]C(OC)=O)=[CH:19][C:4]=1[NH:5][C:6]1[C:15]2[C:10](=[CH:11][C:12]([OH:18])=[C:13]([O:16][CH3:17])[CH:14]=2)[N:9]=[CH:8][N:7]=1.[C:29]([NH:32][C:33]1[S:34][CH:35]=[C:36]([CH2:38]Cl)[N:37]=1)(=[O:31])[CH3:30]>>[C:29]([NH:32][C:33]1[S:34][CH:35]=[C:36]([CH2:38][O:18][C:12]2[CH:11]=[C:10]3[C:15]([C:6]([NH:5][C:4]4[CH:19]=[C:20]([OH:24])[C:21]([CH3:23])=[CH:22][C:3]=4[F:2])=[N:7][CH:8]=[N:9]3)=[CH:14][C:13]=2[O:16][CH3:17])[N:37]=1)(=[O:31])[CH3:30]

参加物

3

反応物 2

HCID 819632-Acetamido-4-chloromethylthiazoleHCID 1356711794-(2-Fluoro-5-methoxycarbonyloxy-4-methylanilino)-7-hydroxy-6-methoxyquinazoline hydrochloride

生成物 1

HCID 158860467-((2-Acetamidothiazol-4-yl)methoxy)4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxyquinazoline収率 25.2%

実験手順

Using an analogous procedure to that described in Example 27, 4-(2-fluoro-5-methoxycarbonyloxy-4-methylanilino)-7-hydroxy-6-methoxyquinazoline hydrochloride (470 mg 1.14 mmol), (prepared as described for the starting material in Example 22), and 2-acetamido-4-chloromethylthiazole (381 mg, 1.68 mmol) were combined to give 7-((2-acetamidothiazol-4-yl)methoxy)-4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxyquinazoline (135 mg, 25%).

後処理

  1. custom(prepared

出典と根拠

ORDレコード
ord-7198824a60df458f987d79be9057038c
出典データセット
uspto-grants-2002_03
特許番号
US06362336B1

関連ノート

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