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Thionyl Chloride → 2-(Chloromethyl)-1-methylbenzimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | (1-methyl-1H-1,3-benzodiazol-2-yl)methanol | HCID 344177 | — |
| 生成物 | 2-(Chloromethyl)-1-methylbenzimidazole | HCID 248044 | 36% |
反応手順
A solution of 2-hydroxymethyl-1-methylbenzimidazole (1.1 g, 6.7 mmol) in thionyl chloride (10 ml) was stirred at ambient temperature for 15 minutes and then heated at reflux for 15 minutes. The volatiles were removed by evaporation and the residue purified by column chromatography eluting with methylene chloride/methanol (95/5) to give 2-chloromethyl-1-methylbenzimidazole (506 mg, 36%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06362336B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-d8c3115e42f34c5791ca6054fb4ab195 |
| 出典メモ | uspto-grants-2002_03 |