4-Chloropyridine → 3-(N-methyl-N-(4-pyridyl)amino)propanol
反応式
Cl[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[CH3:8][NH:9][CH2:10][CH2:11][CH2:12][OH:13]>>[CH3:8][N:9]([CH2:10][CH2:11][CH2:12][OH:13])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1参加物
3
実験手順
Using a procedure analogous to that described for the starting material in Example 46, 4-chloropyridine (885 mg, 59 mmol) and 3-(methylamino)propanol (2.1 g, 0.23 mmol), (Tetrahedron Lett. 1994, 35, 1545-1548), were heated for 8 hours to give 3-(N-methyl-N-(4-pyridyl)amino)propanol (979 mg, 61%).
後処理
- temperaturewere heated for 8 hours
出典と根拠
- ORDレコード
- ord-ad9e9ab02d9249ee8a8296d145b7db35
- 出典データセット
- uspto-grants-2002_03
- 特許番号
- US06362336B1
反応ノート
読み込み中…