化工社化工社 化学情報印刷レポート · 研究参考用
Formamide → 7-Fluoroquinazolin-4(3H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formamide | HCID 713 | — |
| 反応物 | 4-Fluoroanthranilic acid | HCID 2724967 | — |
| 反応物 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | 7-Fluoroquinazolin-4(3H)-one | HCID 135398496 | 82% |
反応手順
A solution of 2-amino-4-fluorobenzoic acid (3 g, 19.3 mmol) in formamide (30 ml) was heated at 150° C. for 6 hours. The reaction mixture was poured onto ice/water 1/1 (250 ml). The precipitated solid was collected by filtration, washed with water and dried to give 7-fluoro-3,4-dihydroquinazolin-4-one (2.6 g, 82%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06362336B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-e76a6d410ada441f9c6dab92f41e4816 |
| 出典メモ | uspto-grants-2002_03 |