化工社化工社 化学情報印刷レポート · 研究参考用
Propionic Acid → 1-(2-Ethyl-4-methyloxazol-5-yl)ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Propionic Acid | HCID 1032 | — |
| 反応物 | Propionamide | HCID 6578 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 3-Chloro-2,4-pentanedione | HCID 74328 | — |
| 生成物 | 1-(2-Ethyl-4-methyloxazol-5-yl)ethanone | HCID 18936328 | — |
反応手順
3-Chloropentane-2,4-dione (46.5 g), propionamide (50 g) and propionic acid (151 g) were heated at 145° C. for 5 hours. The mixture was cooled to room temperature, then basified to pH 10 using 10M aqueous sodium hydroxide, and extracted with dichloromethane. The combined extracts were washed with brine, dried and the solvent removed to leave a brown oil which was purified by vacuum distillation, b.p. 70° C. at 2 mbar.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05731335 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-eb5bfefcbfd94ea0be77c604cb53b9bd |
| 出典メモ | uspto-grants-1998_03 |