Dimethylformamide → HCID 14456868、化合物

HRID 279782ノート

反応式

HRID 279782 の反応式
[CH3:1][O:2][C:3]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:4]=1[CH2:5][N:6]1[CH:9]([CH2:10]I)[CH2:8][C:7]1=[O:12].[CH3:19][N:20](C)C=O.[C-]#N.[Na+]>O>[C:19]([CH2:10][CH:9]1[N:6]([CH2:5][C:4]2[CH:13]=[CH:14][C:15]([O:17][CH3:18])=[CH:16][C:3]=2[O:2][CH3:1])[C:7](=[O:12])[CH2:8]1)#[N:20]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 8929Sodium CyanideHCID 14456867HCID 14456867、化合物

生成物 1

HCID 14456868HCID 14456868、化合物収率 70%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 1.2 g (3.3 millimoles) of 1-(2,4-dimethoxy-benzyl)-4-iodomethyl-2-azetidinone and 5 ml of dimethyl formamide is stirred with 0.35 g (7 millimoles) of sodium cyanide at room temperature for 48 hours. The solution is poured onto 30 ml of water and extracted five times with 20 ml of ether each. The etheral solution is dried over anhydrous magnesium sulfate, filtered and the filtrate is evaporated in vacuo. Thus 0.6 g of 4-cyanomethyl-1-(2,4-dimethoxy-benzyl)-2-azetidinone are obtained. Yield: 70%.

後処理

  1. extractionextracted five times with 20 ml of ether each
  2. dry with materialThe etheral solution is dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customthe filtrate is evaporated in vacuo

出典と根拠

ORDレコード
ord-7f060409e59a45c5ae2a43fc44b3b30b
出典データセット
uspto-grants-1986_05
特許番号
US04587049

反応ノート

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