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Sodium hydride → 1-t-Butoxycarbonylmethyl-3-azido-8-methylperhydroazocin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Tert-butyl 2-iodoacetate | HCID 11021060 | — |
| 反応物 | 3-Azido-8-methylperhydroazocin-2-one | HCID 13608312 | — |
| 生成物 | 1-t-Butoxycarbonylmethyl-3-azido-8-methylperhydroazocin-2-one | HCID 23322535 | — |
反応手順
React 5.65 g of this azide with 7.9 g t-butyl iodoacetate and 0.82 g sodium hydride as described in Example 1 to obtain 1-t-butoxycarbonylmethyl-3-azido-8-methylperhydroazocin-2-one, which can be purified by chromatography over silica gel. NMR (CCl4, TMS): δ 1.0-2.2 (m); δ 1.3 (d); δ 1.45 (s); δ 3.45 (d, J=16h3); δ 3.95 (d, J-16h3); δ 4.3-5.1 (m).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04587050 |
| 出典データセット | uspto-grants-1986_05 |
| ORD ID | ord-b484811a8fa94bda97e3b37dc6d321c0 |
| 出典メモ | uspto-grants-1986_05 |