関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Succinic anhydride | HCID 7922 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Methyl thyroxinate hydrochloride | HCID 13911220 | — |
| 生成物 | Thyroxine | HCID 5819 | — |
反応手順
In 150 ml of dried tetrahydrofuran 1.65 g (0.002 mol) of thyroxine methyl ester hydrochloride was dissolved. To the resulting solution 300 μl (0.0021 mol) of triethyl amine and 200 mg. (0.0022 mol) of succinic anhydride were added. The mixture was stirred at 4° C. overnight to effect reaction.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04587102 |
|---|
| 出典データセット | uspto-grants-1986_05 |
|---|
| ORD ID | ord-d6e33fbb8e70494a89adc8bd3b8100b1 |
|---|
| 出典メモ | uspto-grants-1986_05 |
|---|
