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Triethylamine → Methylprednisolone Aceponate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 21-Acetoxy-6alpha-methyl-17-propionyloxy-11beta-trifluoroacetoxy-1,4-pregnadiene-3,20-dione | HCID 70466885 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methylprednisolone Aceponate | HCID 63019 | 79.1% |
反応手順
3.5 g of 21-acetoxy-6α-methyl-17-propionyloxy-11β-trifluoroacetoxy-1,4-pregnadiene-3,20-dione is stirred in 80 ml of methanol and 4.2 ml of triethylamine for 4 hours at room temperature. The crude product is purified on 600 g of silica gel with a methylene chloride-acetone gradient (0-15% acetone), thus isolating 2.3 g of 21-acetoxy-11β-hydroxy-6α-methyl-17-propionyloxy-1,4-pregnadiene-3,20-dione.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04587236 |
| 出典データセット | uspto-grants-1986_05 |
| ORD ID | ord-9b7f0fd4dda74cedad7c2476c5fb953e |
| 出典メモ | uspto-grants-1986_05 |