4-Methylcyclohexanone → Methyl (3R)-8-methyl-1-thia-4-azaspiro[4.5]decane-3-carboxylate hydrochloride

HRID 279864

反応式

HRID 279864 の反応式
[ClH:1].[CH3:2][O:3][C:4](=[O:9])[C@H:5]([CH2:7][SH:8])[NH2:6].[CH3:10][CH:11]1[CH2:16][CH2:15][C:14](=O)[CH2:13][CH2:12]1>CO>[ClH:1].[CH3:10][CH:11]1[CH2:16][CH2:15][C:14]2([S:8][CH2:7][C@@H:5]([C:4]([O:3][CH3:2])=[O:9])[NH:6]2)[CH2:13][CH2:12]1

参加物

4

反応物 2

HCID 115254-MethylcyclohexanoneHCID 2733208L-Cysteine, methyl ester, hydrochloride

生成物 1

HCID 86740772Methyl (3R)-8-methyl-1-thia-4-azaspiro[4.5]decane-3-carboxylate hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

34.3 g of L-cysteine methyl ester hydrochloride and 15.4 ml of 4-methylcyclohexanone are suspended in 70 ml of methanol and the suspension is refluxed for 3 hours. The suspension is concentrated to dryness under reduced pressure and the residue is recrystallized from isopropanol/methanol to give 25 g of colorless crystals of melting point 180° C.

後処理

  1. temperaturethe suspension is refluxed for 3 hours
  2. concentrationThe suspension is concentrated to dryness under reduced pressure
  3. customthe residue is recrystallized from isopropanol/methanol

出典と根拠

ORDレコード
ord-8dfe6a8dff9f400ebc720d0b424d8c3a
出典データセット
uspto-grants-1986_05
特許番号
US04587250

関連ノート

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