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Triclosan → 5-Chloro-2-(2,4-dichlorophenoxy)phenyl 2-octanoyloxy-1-(octanoyloxymethyl)ethyl adipate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triclosan | HCID 5564 | — |
| 反応物 | Adipoyl chloride | HCID 61034 | — |
| 反応物 | 1,3-Dioctanoyl glycerol | HCID 150911 | — |
| 生成物 | 5-Chloro-2-(2,4-dichlorophenoxy)phenyl 2-octanoyloxy-1-(octanoyloxymethyl)ethyl adipate | HCID 53798617 | 33% |
反応手順
Using a similar procedure to that described in Example 6, but using 5-chloro-2-(2,4-dichlorophenoxy)phenol, adipoyl dichloride and 2-hydroxy-3-octanoyloxypropyl octanoate as starting materials, there was obtained 5-chloro-2-(2,4-dichlorophenoxy)phenyl 2-octanoyloxy-1-(octanoyloxymethyl)ethyl adipate as an oil in 33% yield; NMR (CDCL3): 0.85 (6H, br.s, CH3), 1.25+1.65 (24H, br.s, CH2), 2.3 (8H, m, COCH2), 4.2 (4H, m, OCH2), 5.25 (1H, m, CH), 6.6-7.5 (6H, complex, aromatic H)ppm.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04587262 |
| 出典データセット | uspto-grants-1986_05 |
| ORD ID | ord-962d4d809c1646448aff1daaf2ff3aae |
| 出典メモ | uspto-grants-1986_05 |