Water → (8aR-trans)-octahydro-1-propyl-6(2H)-quinolinone

HRID 279958

反応式

HRID 279958 の反応式
O.CC1(C)CO[C:6]2([CH2:13][CH2:12][C:11](=[O:14])[CH2:10][CH2:9]2)OC1.[CH2:16]([NH2:19])[CH2:17][CH3:18].O.[C:21]1(C)[CH:26]=CC(S(O)(=O)=O)=C[CH:22]=1>C1(C)C=CC=CC=1>[CH2:16]([N:19]1[C@H:6]2[C@@H:9]([CH2:10][C:11](=[O:14])[CH2:12][CH2:13]2)[CH2:26][CH2:21][CH2:22]1)[CH2:17][CH3:18]

参加物

6

反応物 4

HCID 962WaterHCID 7852PropylamineHCID 521998p-Toluenesulfonic acid monohydrateHCID 5879683,3-Dimethyl-1,5-dioxaspiro(5.5)undecan-9-one

生成物 1

HCID 13457872(8aR-trans)-octahydro-1-propyl-6(2H)-quinolinone

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A 250 ml single neck round bottom flask fitted with a water separator containing 20 g of 3A sieves (Linde) was charged with 100 ml of toluene, 10.25 g (0.052 mol) of 3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-one (Aldrich Chemical Company), 17.97 g (3.04 mmol) of n-propylamine (Baker) and 18 mg (0.09 mmol) of p-toluenesulfonic acid monohydrate (Aldrich). The reaction mixture was refluxed for 24 hours and cooled, and the toluene was evaporated under reduced pressure to produce the title compound.

後処理

  1. temperatureThe reaction mixture was refluxed for 24 hours
  2. temperaturecooled
  3. customthe toluene was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-5a4c264c5471459b8d3a8fecca54cb00
出典データセット
uspto-grants-1986_05
特許番号
US04587351

関連ノート

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