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Hydrochloric Acid → 3-Trifluoroacetylfuran
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethyl trifluoroacetate | HCID 9794 | — |
| 反応物 | 3-Bromofuran | HCID 89164 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 3-Trifluoroacetylfuran | HCID 18936315 | — |
反応手順
3-Bromofuran (20 g) was added to a solution of n-butyllithium (2.5M in hexanes, 60 ml) in diethyl ether (200 ml) at -70° C. After 30 minutes, ethyl trifluoroacetate (28.6 g) was added slowly. After a further 1 hour the mixture was allowed to warm to room temperature and was then left to stir overnight. 1M Hydrochloric acid (100 ml) was added and the mixture stirred for 5 minutes. The organic layer was separated, washed, dried and evaporated. The residue was distilled to give the title compound. B.p. 118° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05731335 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-ca2c656728094237986dc15e1b9e16c6 |
| 出典メモ | uspto-grants-1998_03 |