Sodium Methoxide → 7-Bromo-2-methoxy-4-methylquinoline

HRID 280000ノート

反応式

HRID 280000 の反応式
Cl[C:2]1[CH:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][C:6]([Br:13])=[CH:7][CH:8]=2)[N:3]=1.[CH3:14][O-:15].[Na+]>CO>[CH3:14][O:15][C:2]1[CH:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][C:6]([Br:13])=[CH:7][CH:8]=2)[N:3]=1

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 145703037-Bromo-2-chloro-4-methylquinoline

生成物 1

HCID 145703057-Bromo-2-methoxy-4-methylquinoline収率 89.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 3.00 g (12.00 mM) of 2-chloro-4-methyl-7-bromoquinoline and 0.63 g (12.00 mM) of sodium methoxide was heated to reflux in 30 mL of dry methanol for 48 h. The methanol was then removed in vacuo, and the resultant concentrate was taken up in methylene chloride. This methylene chloride solution was washed repeatedly with saturated sodium chloride. After drying (MgSO4), solvent removal, and recrystallisation from toluene, 2.63 g (87%) of the product was obtained as white crystals: mp 58°-60° C.

後処理

  1. temperaturewas heated
  2. customThe methanol was then removed in vacuo
  3. concentrationthe resultant concentrate
  4. washThis methylene chloride solution was washed repeatedly with saturated sodium chloride
  5. customAfter drying
  6. custom(MgSO4), solvent removal, and recrystallisation from toluene

出典と根拠

ORDレコード
ord-472bb6864b6445498dd82e522fb16917
出典データセット
uspto-grants-1986_05
特許番号
US04587341

反応ノート

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