化工社化工社 化学情報印刷レポート · 研究参考用
Diethyl Ether → N-(3-hydroxypropyl)-2,3,4-trimethoxy-benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | 3-Amino-1-propanol | HCID 9086 | — |
| 反応物 | 2,3,4-trimethoxybenzenesulfonyl Chloride | HCID 4712742 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(3-hydroxypropyl)-2,3,4-trimethoxy-benzenesulfonamide | HCID 13645632 | — |
反応手順
2,3,4-Trimethoxybenzene sulfonyl chloride (20.4 g, 0.765 m) in methylene chloride (100 ml) was added dropwise to 3-aminopropanol (17.2 g) in methylene chloride (300 ml). After stirring overnight the reaction was washed with dilute aqueous HCl, dried and stripped to provide a solid. Trituration with diethyl ether provided the product N-(3-hydroxypropyl)-2,3,4-trimethoxy-benzenesulfonamide, m.p. 95°-97° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04587360 |
| 出典データセット | uspto-grants-1986_05 |
| ORD ID | ord-2a8de3b233524fb4987aa632861c0049 |
| 出典メモ | uspto-grants-1986_05 |