Cyclopropylamine → HCID 178471877、化合物
反応式
[CH:1]1([NH2:4])[CH2:3][CH2:2]1.[F:5][C:6]1[C:23]([F:24])=[C:22]([F:25])[C:21]([F:26])=[CH:20][C:7]=1[C:8]([C:10](=[CH:16]OCC)[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:9]>C(O)C>[F:5][C:6]1[C:23]([F:24])=[C:22]([F:25])[C:21]([F:26])=[CH:20][C:7]=1[C:8]([C:10](=[CH:16][NH:4][CH:1]1[CH2:3][CH2:2]1)[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:9]参加物
4
実験手順
23.2 g of cyclopropylamine are added dropwise to a solution of 123.9 g of ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-ethoxyacrylate in 250 ml of ethanol, cooling in ice and stirring. When the exothermic reaction has subsided, the mixture is stirred at room temperature for 1 hour, the solvent is removed in vacuo, and the residue is recrystallized from cyclohexane/petroleum ether. 115 g of ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-cyclopropylaminoacrylate of melting point 63°-65° C. are obtained.