HCID 178487720、化合物 → Isoxazolo(4,5-c)quinolin-3(2H)-one, 7-methoxy-2-phenyl-
反応式
O[N:2]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:3]([C:5]1[CH:6]=[N:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10]([O:16][CH3:17])[CH:9]=2)=[O:4]>O>[CH3:17][O:16][C:10]1[CH:11]=[CH:12][C:13]2[C:14]3[O:15][N:2]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[C:3](=[O:4])[C:5]=3[CH:6]=[N:7][C:8]=2[CH:9]=1参加物
3
実験手順
Using the procedure of Step B of Example 2, 3.68 g of N,4-dihydroxy-7-methoxy-N-phenyl-3-quinoline carboxamide were reacted and after 18 hours at ambient temperature, the reaction mixture was poured into water and the products which crystallized were extracted with dichloromethane. The organic phase was washed with water and the solvent was eliminated. The residue was chromatographed on silica and eluted with a mixture of methylene chloride-ethyl acetate (9-1) to obtain 0.7 g of 7-methoxy-2-phenylisoxazolo(4,5-c)quinolin-3-(2H)-one melting at 170° C.
後処理
- customwere reacted and after 18 hours at ambient temperature