Methylamine → 1-Amino-2-(2-fluorobenzoyl)pyrrole
反応式
[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=1[C:4]([C:6]1[N:7]([N:11]2C(=O)C3=CC=CC=C3C2=O)[CH:8]=[CH:9][CH:10]=1)=[O:5].CN>CN(C=O)C.O>[NH2:11][N:7]1[CH:8]=[CH:9][CH:10]=[C:6]1[C:4](=[O:5])[C:3]1[CH:22]=[CH:23][CH:24]=[CH:25][C:2]=1[F:1]参加物
5
実験手順
To a suspension of 2-(2-fluorobenzoyl)-1-phthalimidopyrrole (12.5 g, 27 mmole) in 40 ml DMF was added 40 ml methylamine (40% solution in water). After stirring one hour at ambient temperature, the reaction mixture was diluted with water and extracted with ether. The organic extract was washed with water and with saturated NaCl solution, dried over anhydrous MgSO4, filtered and evaporated to 9 L g oil, half of which was purified by Kugelrohr distillation (120°-130° at 0.2 mm Hg) to give 3.5 g (93%) solid, m.p. 44°-47°.
後処理
- extractionextracted with ether
- extractionThe organic extract
- washwas washed with water and with saturated NaCl solution
- dry with materialdried over anhydrous MgSO4
- filtrationfiltered
- customevaporated to 9 L g oil, half of which
- distillationwas purified by Kugelrohr distillation (120°-130° at 0.2 mm Hg)
出典と根拠
- ORDレコード
- ord-dc1a0d691de7435da2494afb2f5a93d6
- 出典データセット
- uspto-grants-1986_05
- 特許番号
- US04588727
反応ノート
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