Water → HCID 178487220、化合物

HRID 280161ノート

反応式

HRID 280161 の反応式
[C:1]([CH:3]1[C:6]2=[CH:7][C:8]([O:11][CH3:12])=[CH:9][CH:10]=[C:5]2[CH2:4]1)#N.[OH-:13].[K+].[OH2:15]>C(O)C.CCOCC>[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:5]2[CH:4]=[C:3]([C:1]([OH:15])=[O:13])[C:6]=2[CH:7]=1

参加物

6

反応物 3

HCID 962Water2 回HCID 14797Potassium HydroxideHCID 12238660Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, 4-methoxy-

生成物 1

HCID 178487220HCID 178487220、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

1-Cyano-5-methoxybenzocyclobutene (29 g) is stirred with saturated KOH in ethanol (180 ml) for about 12 hours under nitrogen at RT. Water (60 ml) is added to the reaction mixture which is refluxed for about 3 hours. The mixture is cooled to RT, diluted with water, washed with ether and the aqueous layer acidified forming an oil. The oil is dissolved in ether and the ethereal solution washed, dried over Na2SO4, filtered and evaporated in vacuo affording the desired product as an oil.

後処理

  1. temperatureis refluxed for about 3 hours
  2. washwashed with ether
  3. customthe aqueous layer acidified forming an oil
  4. washthe ethereal solution washed
  5. dry with materialdried over Na2SO4
  6. filtrationfiltered
  7. customevaporated in vacuo

出典と根拠

ORDレコード
ord-0d2bf00a0ce748859ba871c82926861f
出典データセット
uspto-grants-1986_05
特許番号
US04588719

反応ノート

読み込み中…