Triethylamine → HCID 131714665、化合物

HRID 280163ノート

反応式

HRID 280163 の反応式
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[CH3:6][O:7][C:8]1[CH:9]=[C:10]2[CH:13]([CH2:14][OH:15])[CH2:12][C:11]2=[CH:16][CH:17]=1.C(N(CC)CC)C>C(Cl)Cl>[S:2]([OH:4])(=[O:7])(=[O:3])[CH3:1].[CH3:6][O:7][C:8]1[CH:9]=[C:10]2[CH:13]([CH2:14][OH:15])[CH2:12][C:11]2=[CH:16][CH:17]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 13247995(4-Methoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanol

生成物 1

HCID 131714665HCID 131714665、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

Methane sulphonyl chloride (13.4 ml) is added dropwise to a stirred solution of 5-methoxy-1-hydroxymethyl benzocyclobutene (26 g) and triethylamine (26.5 ml) in methylene chloride (670 ml) cooled to 0° C. under nitrogen. The reaction mixture is allowed to warm to RT, stirred for 2 hours at RT, washed with water and saturated salt, dried over Na2SO4, and filtered. The filtrate is concentrated in vacuo yielding the desired product as a liquid.

後処理

  1. temperatureto warm to RT
  2. washwashed with water and saturated salt
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationThe filtrate is concentrated in vacuo

出典と根拠

ORDレコード
ord-ff6fc16c6b2a498f8e4a67e73d9d5ef0
出典データセット
uspto-grants-1986_05
特許番号
US04588719

反応ノート

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