3-Ethylsulfanyl-imidazo[1,5-a]pyridine-5-carbaldehyde → Imidazo(1,5-a)pyridine-5-carbaldehyde

HRID 280202ノート

反応式

HRID 280202 の反応式
[CH:1]([C:3]1[N:8]2[C:9](SCC)=[N:10][CH:11]=[C:7]2[CH:6]=[CH:5][CH:4]=1)=[O:2]>C(O)(C)C.[Ni]>[CH:1]([C:3]1[N:8]2[CH:9]=[N:10][CH:11]=[C:7]2[CH:6]=[CH:5][CH:4]=1)=[O:2]

参加物

4

反応物 1

HCID 132061623-Ethylsulfanyl-imidazo[1,5-a]pyridine-5-carbaldehyde

生成物 1

HCID 13206163Imidazo(1,5-a)pyridine-5-carbaldehyde

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 3776Isopropanol溶媒

実験手順

To a solution of 20 g of 5-formyl-3-ethylthioimidazo[1,5-a]pyridine in 200 ml of isopropanol is added approximately 15 g of Raney nickel. The reaction mixture is stirred and heated at reflux temperature for 16 hours. The catalyst is removed by filtration through celite. The filtrate is evaporated under reduced pressure to yield an oily residue. This is purified by column chromatography on silica gel using a mixture of diethyl ether and ethyl acetate (2:1) as eluent. Evaporation of the solvent under reduced pressure yields 5-formylimidazo[1,5-a]pyridine melting at 138°-140°.

後処理

  1. temperatureheated
  2. temperatureat reflux temperature for 16 hours
  3. customThe catalyst is removed by filtration through celite
  4. customThe filtrate is evaporated under reduced pressure
  5. customto yield an oily residue
  6. customThis is purified by column chromatography on silica gel using
  7. additiona mixture of diethyl ether and ethyl acetate (2:1) as eluent
  8. customEvaporation of the solvent under reduced pressure

出典と根拠

ORDレコード
ord-8172b72dadb84d23a6256413e4863b03
出典データセット
uspto-grants-1986_05
特許番号
US04588732

反応ノート

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