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4-Nitrophenol → Diethyl[2-(4-nitrophenoxy)ethyl]amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Nitrophenol | HCID 980 | — |
| 反応物 | Diethylaminoethyl chloride | HCID 13364 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Diethyl[2-(4-nitrophenoxy)ethyl]amine | HCID 88294 | — |
反応手順
To a cold solution of 41.8 g of 4-nitrophenol in 250 ml of DMF was added 16.0 g of a 57% dispersion of sodium hydride in mineral oil, followed by 46.0 g of 2-diethylaminoethyl chloride. After 20 hours, the mixture was filtered, freed of solvent by evaporation under reduced pressure, the residue dissolved in ether and washed with water. Extraction with 2N hydrochloric acid and basification of the extract gave N,N-diethyl-2-(4-nitrophenoxy)ethanamine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04588730 |
| 出典データセット | uspto-grants-1986_05 |
| ORD ID | ord-8642a758cc744568a9c3812c649ac4ca |
| 出典メモ | uspto-grants-1986_05 |