化工社化工社 化学情報印刷レポート · 研究参考用
4-Benzyloxyphenylacetaldehyde → HCID 23322068、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Benzyloxyphenylacetaldehyde | HCID 11413489 | — |
| 反応物 | 4-(2-Aminoethyl)-1,3-dihydro-2H-indol-2-one | HCID 23322037 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | HCID 23322068 | HCID 23322068 | — |
反応手順
A mixture of 0.9 g of 4-(2-aminoethyl)-2(3H)-indolone, 0.23 g of 4-benzyloxyphenylacetaldehyde, 0.25 g of 10% palladium-on-charcoal and 100 ml of ethanol is hydrogenated at 50 p.s.i. at 50° until the uptake of hydrogen is complete. After filtration, the mother liquors are evaporated to give 4-[2-(4-hydroxyphenethylamino)-ethyl]-2(3H)-indolone as the residue. This base in alcohol is treated with an excess of methanesulfonic acid to give the methanesulfonate salt.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04588740 |
| 出典データセット | uspto-grants-1986_05 |
| ORD ID | ord-c7c7e9eb37c648118c095d56bb37f520 |
| 出典メモ | uspto-grants-1986_05 |