Water → 4-Methyl-2-trifluoroacetyloxazole
反応式
[F:1][C:2]([F:11])([F:10])[C:3](N1C=CN=C1)=[O:4].[CH3:12][C:13]1[N:14]=[C:15]([Si](C)(C)C)[O:16][CH:17]=1.O>C(OCC)C>[CH3:12][C:13]1[N:14]=[C:15]([C:3](=[O:4])[C:2]([F:11])([F:10])[F:1])[O:16][CH:17]=1参加物
5
実験手順
1-Trifluoroacetylimidazole (10 g) was added dropwise to 4-methyl-2-trimethylsilyloxazole (J. Chem. Soc., Chem. Commun., 1984, 258) (9.95 g) in diethyl ether (100 ml) at 0° C. under an atmosphere of dry nitrogen. The mixture was stirred overnight at room temperature. Water was added and the organic layer was separated, washed, dried and evaporated. Flash chromatography gave the title compound.
後処理
- customthe organic layer was separated
- washwashed
- customdried
- customevaporated
出典と根拠
- ORDレコード
- ord-4117f1caea15466f91091f87c8c7eae4
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05731335
反応ノート
読み込み中…