化工社化工社 化学情報印刷レポート · 研究参考用
2-Amino-1-(3-fluorophenyl)ethan-1-ol → N-(2-(4-Methylphenyl)-1-methylethyl)-2-hydroxy-2-(3-fluorophenyl)ethanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-1-(3-fluorophenyl)ethan-1-ol | HCID 35800 | — |
| 反応物 | Fumaric Acid | HCID 444972 | — |
| 反応物 | 2-Amino-1-(3-chlorophenyl)ethan-1-ol | HCID 3751601 | — |
| 生成物 | N-(2-(4-Methylphenyl)-1-methylethyl)-2-hydroxy-2-(3-fluorophenyl)ethanamine | HCID 23322168 | — |
反応手順
The title compound was prepared in the manner described in Example 3 replacing 2-(3-chlorophenyl)-2-hydroxyethanamine with 2-(3-fluorophenyl)-2-hydroxyethanamine. The chromatographed material was treated with methanolic fumaric acid and the derived salt recrystallised from ethyl acetate to give the title compound (fumarate), mp 58-83, as a 52-48 mixture of diastereoisomers.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04588749 |
| 出典データセット | uspto-grants-1986_05 |
| ORD ID | ord-cae322d37bd94ec9aae0e1baf9fe6a28 |
| 出典メモ | uspto-grants-1986_05 |