Phenylglyoxal → HCID 23322164、化合物

HRID 280318ノート

反応式

HRID 280318 の反応式
[C:1]1([C:7]([CH:9]=O)=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:11][C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[CH2:19][CH:20]([CH3:22])[NH2:21]>>[CH3:11][C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[CH2:19][CH:20]([NH:21][CH2:9][CH:7]([OH:8])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH3:22]

参加物

3

反応物 2

HCID 14090PhenylglyoxalHCID 541870α,2,4-Trimethylbenzeneethanamine

生成物 1

HCID 23322164HCID 23322164、化合物

実験手順

The title compound was prepared in the manner described in Example 9 using phenylglyoxal and 2-(2,4-dimethylphenyl)-1-methylethanamine. The residual oil was chromatographed on Kieselgel 60 using 3% methanol-chloroform. Recrystallization of the resulting solid from hexane gave the title compound m.p. 91-92 as a 6:94 mixture of diastereoisomers. τ(CDCl3) 8.9 (3H, d, J=6 Hz), 7.7 (6H, s), 6.9-7.6 (5H, (m) +2H, disappears with D2O) 5.35 (1H, m), 3.05 (3H, s), 2.68 (5H, m).

後処理

  1. customThe title compound was prepared in the manner
  2. customThe residual oil was chromatographed on Kieselgel 60 using 3% methanol-chloroform
  3. customRecrystallization of the resulting solid from hexane

出典と根拠

ORDレコード
ord-33c0f56da80248e6a6139b4be30369e5
出典データセット
uspto-grants-1986_05
特許番号
US04588749

反応ノート

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