Dimethyl N-cyanodithioiminocarbonate → HCID 178503923、化合物
反応式
[C:1]([N:3]=[C:4](SC)[S:5][CH3:6])#[N:2].[NH2:9][CH2:10][CH2:11][N:12]1[CH2:17][CH2:16][CH:15]([NH:18][C:19]2[N:27]([CH2:28][C:29]3[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=3)[C:22]3=[N:23][CH:24]=[CH:25][CH:26]=[C:21]3[N:20]=2)[CH2:14][CH2:13]1>CO>[C:1]([N:3]=[C:4]([S:5][CH3:6])[NH:9][CH2:10][CH2:11][N:12]1[CH2:17][CH2:16][CH:15]([NH:18][C:19]2[N:27]([CH2:28][C:29]3[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=3)[C:22]3=[N:23][CH:24]=[CH:25][CH:26]=[C:21]3[N:20]=2)[CH2:14][CH2:13]1)#[N:2]参加物
4
実験手順
A mixture of 1.9 parts of dimethyl cyanocarbonimidodithioate, 4.8 parts of N-[1-(2-aminoethyl)-4-piperidinyl]-3-[(4-fluorophenyl)-methyl]-3H-imidazo[4,5-b]pyridin-2-amine and 80 parts of methanol was stirred for 2 hours at room temperature. The reaction mixture was evaporated and the residue was crystallized from acetonitrile, yielding 4.5 parts (74%) of S-methyl N'-cyano-N-[2-[4-[[3-[(4-fluorophenyl)methyl]-3H-imidazo[4,5-b]pyridin-2-yl]amino]-1-piperidinyl]ethyl]carbamimidothioate; mp. 172.2° C. (compound 21).