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p-Toluenesulfonic acid → 3H,5H-Pyrrolo[1,2-c]oxazol-5-one, tetrahydro-3,3-dimethyl-, (R)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | 2,2-Dimethoxypropane | HCID 6495 | — |
| 反応物 | 5-(Hydroxymethyl)pyrrolidin-2-one | HCID 558359 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3H,5H-Pyrrolo[1,2-c]oxazol-5-one, tetrahydro-3,3-dimethyl-, (R)- | HCID 13746929 | — |
反応手順
A mixture of 5-hydroxymethyl-2-pyrrolidone (0.3 g) and 2,2-dimethoxypropane (2 ml) in dichloromethane was refluxed in the presence of a crystal (ca. 10 mg.) of p-toluenesulfonic acid for 20 hours. Aqueous extractive work up followed by solvent evaporation produced 0.18 g of (R)-tetrahydro-3,3-dimethyl-3H,5H-pyrrolo[1,2-c]oxazol-5-one as an oil (TLC showed a single spot at Rf =0.6 (ethyl acetate)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04588819 |
| 出典データセット | uspto-grants-1986_05 |
| ORD ID | ord-1c369197f2a84a4497edde5f62b30af8 |
| 出典メモ | uspto-grants-1986_05 |