化工社化工社 化学情報印刷レポート · 研究参考用
Aluminum isopropoxide → Thiazole, 5-(methoxymethyl)-4-methyl-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Aluminum isopropoxide | HCID 11143 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4-Methylthiazole-5-carboxaldehyde | HCID 581339 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 溶媒 | Methyl iodide | HCID 6328 | — |
| 溶媒 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 生成物 | Thiazole, 5-(methoxymethyl)-4-methyl- | HCID 11571819 | — |
反応手順
4-Methyl-5-thiazolecarbaldehyde (J. Amer. Chem. Soc., 1982, 104, 4934-4943) was reduced using aluminium isopropoxide in 2-propanol. The resulting alcohol was treated with sodium hydride in dimethoxyethane and iodomethane was added. Distillation gave the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05731335 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-7f93372015354dc38e885820152952ed |
| 出典メモ | uspto-grants-1998_03 |