Aluminum isopropoxide → Thiazole, 5-(methoxymethyl)-4-methyl-

HRID 2804

反応式

HRID 2804 の反応式
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH:7]=[O:8].[CH3:9]C(C)[O-].[Al+3].CC(C)[O-].CC(C)[O-].[H-].[Na+]>CC(O)C.C(COC)OC.IC>[CH3:9][O:8][CH2:7][C:6]1[S:5][CH:4]=[N:3][C:2]=1[CH3:1]

参加物

7

反応物 3

HCID 11143Aluminum isopropoxideHCID 24758Sodium hydrideHCID 5813394-Methylthiazole-5-carboxaldehyde

生成物 1

HCID 11571819Thiazole, 5-(methoxymethyl)-4-methyl-

試薬・触媒・溶媒 3

HCID 3776Isopropanol溶媒HCID 6328Methyl iodide溶媒HCID 80711,2-Dimethoxyethane溶媒

実験手順

4-Methyl-5-thiazolecarbaldehyde (J. Amer. Chem. Soc., 1982, 104, 4934-4943) was reduced using aluminium isopropoxide in 2-propanol. The resulting alcohol was treated with sodium hydride in dimethoxyethane and iodomethane was added. Distillation gave the title compound.

後処理

  1. additionwas added
  2. distillationDistillation

出典と根拠

ORDレコード
ord-7f93372015354dc38e885820152952ed
出典データセット
uspto-grants-1998_03
特許番号
US05731335

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