Dimethylamine → N'-{4-[(1,2-Benzothiazol-5-yl)oxy]-3-chlorophenyl}-N,N-dimethylurea
反応式
[CH3:1][NH:2][CH3:3].[Cl:4][C:5]1[CH:20]=[C:19]([N:21]=[C:22]=[O:23])[CH:18]=[CH:17][C:6]=1[O:7][C:8]1[CH:9]=[CH:10][C:11]2[S:15][N:14]=[CH:13][C:12]=2[CH:16]=1>C(OCC)C>[Cl:4][C:5]1[CH:20]=[C:19]([NH:21][C:22]([N:2]([CH3:3])[CH3:1])=[O:23])[CH:18]=[CH:17][C:6]=1[O:7][C:8]1[CH:9]=[CH:10][C:11]2[S:15][N:14]=[CH:13][C:12]=2[CH:16]=1参加物
4
実験手順
5 parts of gaseous dimethylamine were passed into 30.3 parts of 5-(2'-chloro-4'-isocyanatophenoxy)-benzisothiazole and 300 parts of diethyl ether at from 20° to 30° C., the mixture was stirred for 12 hours at this temperature and the resulting precipitate was then isolated and dried. 27.5 parts (70% of theory) of 5-(2'-chloro-4'-dimethylaminocarbonylaminophenoxy)-benzisothiazole of melting point 149° C. were obtained.