Diethyl Ether → HCID 53826873、化合物

反応式

CO[NH:3][CH3:4].[N:5]([C:8]1[CH:23]=[CH:22][C:11]([O:12][C:13]2[CH:14]=[CH:15][C:16]3[S:20][N:19]=[CH:18][C:17]=3[CH:21]=2)=[C:10]([C:24]([F:27])([F:26])[F:25])[CH:9]=1)=[C:6]=[O:7].C([O:30][CH2:31]C)C>>[CH3:31][O:30][N:5]([C:8]1[CH:23]=[CH:22][C:11]([O:12][C:13]2[CH:14]=[CH:15][C:16]3[S:20][N:19]=[CH:18][C:17]=3[CH:21]=2)=[C:10]([C:24]([F:27])([F:26])[F:25])[CH:9]=1)[C:6]([NH:3][CH3:4])=[O:7]

参加物

反応物 3

HCID 3283Diethyl Ether2 回

HCID 14232N,O-Dimethylhydroxylamine

HCID 233204491,2-Benzisothiazole, 5-[4-isocyanato-2-(trifluoromethyl)phenoxy]-

生成物 1

HCID 53826873HCID 53826873、化合物収率 83%

実験手順

A solution of 6.1 parts of N-methoxy-N-methylamine in 100 parts of diethyl ether was added to a solution of 33.6 parts of 5-(4'-isocyanato-2'-trifluoromethylphenoxy)-benzisothiazole in 300 parts of diethyl ether at from 20 to 30° C., the reaction mixture was stirred for 12 hours at this temperature and the resulting precipitate was then isolated. 33 parts (83% of theory) of 5-[4'-(N-methoxy-N-methylaminocarbonylamino)-2'-trifluoromethylphenoxy]-benzisothiazole of melting point 197° C. were obtained.