Hydrochloric Acid → 2-Methylbenzo[b]thiophene-5-carboxylic acid methyl ester

HRID 280593ノート

反応式

HRID 280593 の反応式
[CH3:1][C:2]1[S:6][C:5]2[CH:7]=[CH:8][C:9]([C:11]([OH:13])=[O:12])=[CH:10][C:4]=2[CH:3]=1.Cl.[CH3:15]O>>[CH3:15][O:12][C:11]([C:9]1[CH:8]=[CH:7][C:5]2[S:6][C:2]([CH3:1])=[CH:3][C:4]=2[CH:10]=1)=[O:13]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 1366303686792-71-4

生成物 1

HCID 136630372-Methylbenzo[b]thiophene-5-carboxylic acid methyl ester

実験手順

A solution of 2-methylbenzo[b]thiophene-5-carboxylic acid (17.4 g) in methanol (250 ml) was saturated with hydrogen chloride and then heated under reflux for 30 minutes. The solid which crystallised out on cooling was filtered off and dried to give 2-methylbenzo[b]thiophene-5-carboxylic acid methyl ester (16.7 g), m.p. 97°-98°.

後処理

  1. temperatureheated
  2. temperatureunder reflux for 30 minutes
  3. customThe solid which crystallised out
  4. temperatureon cooling
  5. filtrationwas filtered off
  6. customdried

出典と根拠

ORDレコード
ord-60f6a7c3f90f486e81a98c3f04d62b26
出典データセット
uspto-grants-1986_05
特許番号
US04590200

反応ノート

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