Water → 1-(4-Methyl-5-oxazolyl)-1-(3-thienyl)ethanol

HRID 2806

反応式

HRID 2806 の反応式
Br[C:2]1[CH:6]=[CH:5][S:4][CH:3]=1.C([Li])CCC.[C:12]([C:15]1[O:19][CH:18]=[N:17][C:16]=1[CH3:20])(=[O:14])[CH3:13].O>C(OCC)C>[CH3:20][C:16]1[N:17]=[CH:18][O:19][C:15]=1[C:12]([C:2]1[CH:6]=[CH:5][S:4][CH:3]=1)([OH:14])[CH3:13]

参加物

6

反応物 4

HCID 962WaterHCID 133833-BromothiopheneHCID 110298391-(4-Methyloxazol-5-yl)ethanoneHCID 178418339Butyllithium

生成物 1

HCID 189363241-(4-Methyl-5-oxazolyl)-1-(3-thienyl)ethanol

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒3 回

実験手順

3-Bromothiophene (4.23 g) in diethylether (10 ml) was added dropwise to n-butyllithium (2.5M solution in hexane, 10.4 ml) in dry diethylether (20 ml) at -70° C. under a nitrogen atmosphere. After 3 hours 5-acetyl-4-methyloxazole (2.5 g) in diethylether (10 ml) was added dropwise. After a further 2.5 hours at -70° C., the mixture was allowed to warm to room temperature and then left overnight. The mixture was poured into water and extracted with ether. The product thus obtained was crystallised from diethylether to give 1-(4-methyl-5-oxazolyl)-1-(3-thienyl)ethanol, m.p. 87°-89° C.

後処理

  1. waitleft overnight
  2. extractionextracted with ether
  3. customThe product thus obtained
  4. customwas crystallised from diethylether

出典と根拠

ORDレコード
ord-4d4da764b7ca493a80454e012df84e7d
出典データセット
uspto-grants-1998_03
特許番号
US05731335

関連ノート

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