Hydrochloric Acid → HCID 53739261、化合物

HRID 280614ノート

反応式

HRID 280614 の反応式
[CH3:1][C:2]1[S:6][C:5]2[C:7]([C:11]([OH:13])=[O:12])=[CH:8][CH:9]=[CH:10][C:4]=2[CH:3]=1.Cl.[CH3:15]O>>[CH3:15][O:12][C:11]([C:7]1[C:5]2[S:6][C:2]([CH3:1])=[CH:3][C:4]=2[CH:10]=[CH:9][CH:8]=1)=[O:13]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 126239032-Methyl-1-benzothiophene-7-carboxylic acid

生成物 1

HCID 53739261HCID 53739261、化合物

実験手順

A solution of 2-methylbenzo[b]thiophene-7-carboxylic acid (5.1 g) in methanol (100 ml) was saturated with hydrogen chloride and then heated under reflux for 18 hours. The solution was evaporated and the residue was dissolved in ether. The ether solution was washed with sodium carbonate solution and dried (Na2SO4). Evaporation of the ether gave 2-methylbenzo[b]thiophene-7-carboxylic acid methyl ester (4.7 g), m.p. 48°-49°.

後処理

  1. temperatureheated
  2. temperatureunder reflux for 18 hours
  3. customThe solution was evaporated
  4. dissolutionthe residue was dissolved in ether
  5. washThe ether solution was washed with sodium carbonate solution
  6. dry with materialdried (Na2SO4)
  7. customEvaporation of the ether

出典と根拠

ORDレコード
ord-6f87be024b13420eb8893aea4f40d0c7
出典データセット
uspto-grants-1986_05
特許番号
US04590200

反応ノート

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