Water → 5-Bromo-3-ethyl-1-benzofuran-2-carboxylic acid

HRID 280625ノート

反応式

HRID 280625 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]#N)=[C:7]([CH2:12][CH3:13])[C:6]=2[CH:14]=1.[OH-:15].[K+].[OH2:17]>C(O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]([OH:17])=[O:15])=[C:7]([CH2:12][CH3:13])[C:6]=2[CH:14]=1

参加物

5

反応物 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 23320940HCID 23320940、化合物

生成物 1

HCID 233208915-Bromo-3-ethyl-1-benzofuran-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 5-bromo-3-ethylbenzofuran-2-carbonitrile (2.00 g), potassium hydroxide (1.00 g), water (10 ml) and ethanol (0.5 ml) was heated under reflux for 48 hours and then the solvent was evaporated. The residue was dissolved in water and the solution was filtered and acidified with 2N hydrochloric acid. The solid was filtered off, washed with water and dried to give 5-bromo-3-ethylbenzofuran-2-carboxylic acid (2.01 g) which had m.p. 240°-242° after crystallisation from methanol/H2O.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 48 hours
  3. customthe solvent was evaporated
  4. dissolutionThe residue was dissolved in water
  5. filtrationthe solution was filtered
  6. filtrationThe solid was filtered off
  7. washwashed with water
  8. customdried

出典と根拠

ORDレコード
ord-2f8a87956d3b4e709236744aa13c0038
出典データセット
uspto-grants-1986_05
特許番号
US04590200

反応ノート

読み込み中…