Diphenyl Ether → Methyl-5-(2-chloro-4-cyano-6-fluoro-phenoxy)-2-nitro-benzoate

HRID 280728ノート

反応式

HRID 280728 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:11])[C:9]=1F)[C:5]#[N:6].C1(OC2C=CC=CC=2)C=CC=CC=1.[K].[CH3:26][O:27][C:28](=[O:39])[C:29]1[CH:34]=[C:33]([OH:35])[CH:32]=[CH:31][C:30]=1[N+:36]([O-:38])=[O:37]>CN1CCCC1=O>[CH3:26][O:27][C:28](=[O:39])[C:29]1[CH:34]=[C:33]([O:35][C:9]2[C:8]([F:11])=[CH:7][C:4]([C:5]#[N:6])=[CH:3][C:2]=2[Cl:1])[CH:32]=[CH:31][C:30]=1[N+:36]([O-:38])=[O:37]

参加物

6

反応物 4

HCID 7583Diphenyl EtherHCID 5462222PotassiumHCID 12922678Methyl 5-hydroxy-2-nitrobenzoateHCID 136434703-Chloro-4,5-difluorobenzonitrile

生成物 1

HCID 23035893Methyl-5-(2-chloro-4-cyano-6-fluoro-phenoxy)-2-nitro-benzoate

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

The product 3-chloro-4,5-difluorobenzonitrile, prepared for example as set forth in Example 3, above, is a useful intermediate for the preparation of various end products especially for the preparation of diphenyl ether herbicides. Thus, for example, this compound may be further reacted with the potassium salt of methyl-5-hydroxy-2-nitrobenzoate in a solvent, such as N-methyl-2-pyrrolidone at a temperature of about 120° to 180° Celsius to form methyl-5-(2-chloro-4-cyano-6-fluoro-phenoxy)-2-nitro-benzoate. The ester may be hydrolyzed in a conventional manner to the corresponding carboxylic acid.

後処理

  1. customfor the preparation of various end products

出典と根拠

ORDレコード
ord-9654b819cb6344e78c270f6b659d72c2
出典データセット
uspto-grants-1986_05
特許番号
US04590315

反応ノート

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