HCID 178419747、化合物 → HCID 178419718、化合物

HRID 280743

反応式

HRID 280743 の反応式
Br.[Br:2][CH2:3][C:4]([C:6]([C:8]1[N:9]=[CH:10][NH:11][CH:12]=1)=[O:7])=O.[C:13]([NH:16][C:17]([NH2:19])=[S:18])(=[NH:15])[NH2:14]>CC(C)=O>[BrH:2].[NH:16]([C:17]1[S:18][CH:3]=[C:4]([C:6]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[O:7])[N:19]=1)[C:13]([NH2:15])=[NH:14]

参加物

4

反応物 2

HCID 178419747HCID 178419747、化合物HCID 178513045HCID 178513045、化合物

生成物 1

HCID 178419718HCID 178419718、化合物収率 60%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 0.38 g (1.4 mmol) of 2-bromo-1-(4-imidazoyl)ethanone hydrobromide in 10 ml of acetone was warmed until homogeneous, then 0.17 g (1.4 mmol) of amidinothiourea was added and the mixture was heated at reflux for 0.5 hour. The mixture was cooled and the white precipitate was collected, washed with ether, and dried, thereby affording 0.24 g (60%) of 2-guanidino-4-(4-imidazoyl)thiazole hydrobromide, mp 225° (dec). nmr (DMSO-d6) (δ): 8.20 (s, 1H); 8.0 (b, 4H); 7.77 (s, 1H); 7.36 (s, 1H); high resolution mass spectrum: calcd. C7H8N6S: for 208.0531; found: 208.0517; calcd. for C7H8N6S.HBr.H2O: C, 27.37; H, 3.60; N, 27.36; found: C, 27.23; H, 3.57; N, 27.64.

後処理

  1. additionwas added
  2. temperaturethe mixture was heated
  3. temperatureat reflux for 0.5 hour
  4. temperatureThe mixture was cooled
  5. customthe white precipitate was collected
  6. washwashed with ether
  7. customdried

出典と根拠

ORDレコード
ord-922d650cb64241289e428f4eb9116d5a
出典データセット
uspto-grants-1986_05
特許番号
US04590299

関連ノート

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