Acetyl chloride → 1-Acetyl-4-methylimidazole
反応式
[CH3:1][C:2]1[N:3]=[CH:4][NH:5][CH:6]=1.[C:7](Cl)(=[O:9])[CH3:8]>C1(C)C=CC=CC=1>[C:7]([N:5]1[CH:6]=[C:2]([CH3:1])[N:3]=[CH:4]1)(=[O:9])[CH3:8]参加物
4
実験手順
A mixture of 50 g (609 mmol) of 4-methylimidazole in 250 ml of toluene was stirred at room temperature under nitrogen and 239 g (304 mmol) of acetyl chloride was added. The mixture was stirred at room temperature for 5 hours, filtered to remove insolubles and the filtrate concentrated giving 19 g (50%) of 1- acetyl-4-methyl-imidazole as a yellow oil which crystallizes on standing. nmr (CDCl3) (δ): 8.06 (s, 1H); 7.17 (s, 1H); 2.57 (s, 3H); 2.23 (s, 3H).
後処理
- stirringThe mixture was stirred at room temperature for 5 hours
- filtrationfiltered
- customto remove insolubles
- concentrationthe filtrate concentrated
出典と根拠
- ORDレコード
- ord-4af4ea5dac4647e9b700c221bc95645f
- 出典データセット
- uspto-grants-1986_05
- 特許番号
- US04590299
反応ノート
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