HCID 178432761、化合物 → HCID 178419245、化合物
反応式
[CH3:1][C:2]1[NH:3][C:4]([C:8](=[O:11])[CH2:9][Br:10])=[C:5]([CH3:7])[N:6]=1.[C:12]([NH:15][C:16]([NH2:18])=[S:17])(=[NH:14])[NH2:13]>CC(C)=O>[OH2:11].[BrH:10].[NH:15]([C:16]1[S:17][CH:9]=[C:8]([C:4]2[NH:3][C:2]([CH3:1])=[N:6][C:5]=2[CH3:7])[N:18]=1)[C:12]([NH2:14])=[NH:13].[NH:15]([C:16]1[S:17][CH:9]=[C:8]([C:4]2[NH:3][C:2]([CH3:1])=[N:6][C:5]=2[CH3:7])[N:18]=1)[C:12]([NH2:14])=[NH:13].[BrH:10]参加物
4
実験手順
A solution of 1.0 g (4.6 mmol) of 1-(2,4-dimethyl-5-imidazolyl)-2-bromoethanone in 50 ml of acetone was warmed and 0.55 g (4.6 mmol) of amidinothiourea was added. The mixture was heated at reflux for 1 hour, during which time a white solid precipitated. The precipate was collected, washed with acetone, and dried to give 1.12 g (77%) of 2-guanidino- 4-(2,4-dimethyl-5-imidazolyl)thiazole hydrobromide hemihydrate as a white solid, mp 273° (dc). nmr (D6DMSO) (δ): 8.4-7.2 (b, 7H); 7.00 (s, 1H); 2.50 (s, 3H); 2.38 (s, 3H). Anal. Calcd. for C7H12N6S.HBr.1/2H2O: C, 33.14; H, 4.33; N, 25.76; S. 9.83. Found: C, 33.47; H, 4.19; N, 25.93; S. 9.91.