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4-Chlorophenol → 1-Methyl-2-(2-p-chlorophenoxyethyl)-piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chlorophenol | HCID 4684 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-(2-Chloroethyl)-1-methylpiperidine | HCID 3016566 | — |
| 触媒 | Benzyl triethylammonium chloride | HCID 66133 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-Methyl-2-(2-p-chlorophenoxyethyl)-piperidine | HCID 23339173 | — |
反応手順
200 ml of 50% aqueous sodium hydroxide solution and 1 g of triethylbenzylammonium chloride are added to a solution of 12.8 g of p-chlorophenol in 100 ml of CH2Cl2 ; 16.2 g of 1-methyl-2-(2-chloroethyl)-piperidine are added dropwise, while stirring; and the reaction mixture is stirred for a further one hour. After customary working up, 1-methyl-2-(2-p-chlorophenoxyethyl)-piperidine is obtained. Hydrochloride, m.p. 139°-140°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04225608 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-2812348ef1c64c43accd809c79458783 |
| 出典メモ | uspto-grants-1980_09 |